In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19

In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19

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Background: The progression and severity of COVID-19 vary significantly in the population.While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory Global Analysis of Natural Products Biosynthetic Diversity Encoded in Fungal Genomes parameters are emerging, the impact of sex and age on these profiles is still unknown.Methods: A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2.Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others.Findings: COVID-19 induced similar alterations in laboratory parameters in males and females.

CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women.Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19.Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts CRP, and lactate dehydrogenase.Conclusions: Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex.These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation.